Casagrande is a surname. Notable people with the surname include:
- Alan Casagrande de Moura (born 1987), Brazilian footballer
- Arthur Casagrande (1902–1981), Austrian-American civil engineer
- Caroline Casagrande (born 1976), American politician
- Dominique Casagrande (born 1971), French footballer
- Eloy Casagrande (born 1991), Brazilian drummer
- Francesco Casagrande (born 1970), Italian road racing cyclist
- Jaime Casagrande (died 2013), Brazilian footballer
- Joseph B. Casagrande (1915–1982), American anthropologist
- Marco Casagrande (born 1971), Finnish architect
- June Casagrande, American writer on grammar and usage
- Maurizio Casagrande (born 1961), Italian actor and director
- Walter Casagrande (born 1963), Brazilian footballer