Casein kinase I isoform epsilon or CK1ε, is an enzyme that is encoded by the CSNK1Egene in humans.[5][6] It is the mammalian homolog of doubletime. CK1ε is a serine/threonine protein kinase and is very highly conserved; therefore, this kinase is very similar to other members of the casein kinase 1 family,[7] of which there are seven mammalian isoforms (α, β, γ1, γ2, γ3, δ and ε).[8] CK1ε is most similar to CK1δ in structure and function as the two enzymes maintain a high sequence similarity on their regulatory C-terminal and catalytic domains.[8] This gene is a major component of the mammalian oscillator which controls cellular circadian rhythms.[7] CK1ε has also been implicated in modulating various human health issues such as cancer, neurodegenerative diseases, and diabetes.[8]
^ abCite error: The named reference Knippschild_2015 was invoked but never defined (see the help page).
^ abcYang Y, Xu T, Zhang Y, Qin X (February 2017). "Molecular basis for the regulation of the circadian clock kinases CK1δ and CK1ε". Cellular Signalling. 31: 58–65. doi:10.1016/j.cellsig.2016.12.010. PMID28057520.