Caspase-activated DNase

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

DNA fragmentation factor 40 kDa
DNA fragmentation factor 40 kDa
	Crystal structure of caspase-activated DNAse (CAD)
Identifiers
Symbol	DFF40
Pfam	PF09230
InterPro	IPR015311
SCOP2	1v0d / SCOPe / SUPFAM
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

DFFB
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1IBX
Identifiers
Aliases	DFFB, DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase), CAD, CPAN, DFF-40, DFF2, DFF40, DNA fragmentation factor subunit beta
External IDs	OMIM: 601883; MGI: 1196287; HomoloGene: 3241; GeneCards: DFFB; OMA:DFFB - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	3,885,429 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	154,059,583 bp
RNA expression pattern
	Top expressed in
	cerebellar hemisphere; ; right hemisphere of cerebellum; ; granulocyte; ; endothelial cell; ; Achilles tendon; ; anterior pituitary; ; right ovary; ; mucosa of transverse colon; ; left ovary; ; body of pancreas;
	Top expressed in
	granulocyte; ; morula; ; lumbar subsegment of spinal cord; ; embryo; ; thymus; ; superior frontal gyrus; ; cerebellar cortex; ; embryo; ; jejunum; ; Paneth cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	enzyme binding; nuclease activity; hydrolase activity; protein binding; deoxyribonuclease activity; protein domain specific binding; identical protein binding; disordered domain specific binding;
Cellular component	cytoplasm; cytosol; nucleolus; intracellular anatomical structure; nucleus; nucleoplasm;
Biological process	apoptotic DNA fragmentation; apoptotic chromosome condensation; apoptotic process; DNA catabolic process; protein homooligomerization;
	Sources:Amigo / QuickGO
Orthologs
	1677
	13368
	ENSG00000169598
	ENSMUSG00000029027
	O76075
	O54788
NM_001004285; NM_001004286; NM_001282669; NM_004402; NM_001320132;
	NM_001320136
	NM_007859
	NP_001269598; NP_001307061; NP_001307065; NP_004393
	NP_031885
	Wikidata
View/Edit Human	View/Edit Mouse

Caspase-activated DNase (CAD) or DNA fragmentation factor subunit beta is a protein that in humans is encoded by the DFFB gene.^[5]^[6]^[7] It breaks up the DNA during apoptosis and promotes cell differentiation. It is usually an inactive monomer inhibited by ICAD. This is cleaved before dimerization.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000169598 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029027 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Liu X, Zou H, Slaughter C, Wang X (April 1997). "DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis". Cell. 89 (2): 175–84. doi:10.1016/S0092-8674(00)80197-X. PMID 9108473. S2CID 14800864.
^ Halenbeck R, MacDonald H, Roulston A, Chen TT, Conroy L, Williams LT (April 1998). "CPAN, a human nuclease regulated by the caspase-sensitive inhibitor DFF45". Current Biology. 8 (9): 537–40. Bibcode:1998CBio....8..537H. doi:10.1016/S0960-9822(98)79298-X. PMID 9560346. S2CID 9837862.
^ "Entrez Gene: DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000169598 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029027 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9108473-5] Liu X, Zou H, Slaughter C, Wang X (April 1997). "DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis". Cell. 89 (2): 175–84. doi:10.1016/S0092-8674(00)80197-X. PMID 9108473. S2CID 14800864.

[pmid9560346-6] Halenbeck R, MacDonald H, Roulston A, Chen TT, Conroy L, Williams LT (April 1998). "CPAN, a human nuclease regulated by the caspase-sensitive inhibitor DFF45". Current Biology. 8 (9): 537–40. Bibcode:1998CBio....8..537H. doi:10.1016/S0960-9822(98)79298-X. PMID 9560346. S2CID 9837862.

[entrez-7] "Entrez Gene: DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)".

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