Caspase 8

CASP8
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1F9E, 1I4E, 1QDU, 1QTN, 2C2Z, 2FUN, 2K7Z, 2Y1L, 3H11, 3KJN, 3KJQ, 4JJ7, 4PRZ, 4PS1, 4ZBW
Identifiers
Aliases	CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5, caspase 8
External IDs	OMIM: 601763; MGI: 1261423; HomoloGene: 7657; GeneCards: CASP8; OMA:CASP8 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q33.1 Start 201,233,443 bp[1] End 201,287,711 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 C1.3|1 29.19 cM Start 58,834,533 bp[2] End 58,886,662 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte blood granulocyte buccal mucosa cell bone marrow cells spleen lymph node appendix epithelium of colon rectum Top expressed in jejunum duodenum ileum subcutaneous adipose tissue parotid gland lymph node stroma of bone marrow spleen endothelial cell of lymphatic vessel embryonic cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function death effector domain binding cysteine-type peptidase activity cysteine-type endopeptidase activity involved in apoptotic signaling pathway scaffold protein binding protein binding identical protein binding cysteine-type endopeptidase activity involved in apoptotic process cysteine-type endopeptidase activity hydrolase activity ubiquitin protein ligase binding peptidase activity cysteine-type endopeptidase activity involved in execution phase of apoptosis death receptor binding tumor necrosis factor receptor binding protein-containing complex binding Cellular component cell body cytosol CD95 death-inducing signaling complex ripoptosome nucleoplasm mitochondrial outer membrane death-inducing signaling complex membrane raft neuron projection cytoskeleton cytoplasm mitochondrion nucleus protein-containing complex Biological process regulation of apoptotic process response to estradiol activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway response to antibiotic regulation of tumor necrosis factor-mediated signaling pathway positive regulation of macrophage differentiation cellular response to organic cyclic compound natural killer cell activation negative regulation of I-kappaB kinase/NF-kappaB signaling TRAIL-activated apoptotic signaling pathway proteolysis macrophage differentiation TRIF-dependent toll-like receptor signaling pathway response to tumor necrosis factor B cell activation cell surface receptor signaling pathway response to lipopolysaccharide cellular response to mechanical stimulus activation of cysteine-type endopeptidase activity positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway death-inducing signaling complex assembly positive regulation of proteolysis positive regulation of I-kappaB kinase/NF-kappaB signaling apoptotic signaling pathway response to cold regulation of extrinsic apoptotic signaling pathway via death domain receptors viral process response to ethanol response to cobalt ion activation of cysteine-type endopeptidase activity involved in apoptotic process proteolysis involved in cellular protein catabolic process syncytiotrophoblast cell differentiation involved in labyrinthine layer development nucleotide-binding oligomerization domain containing signaling pathway T cell activation suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process apoptotic process extrinsic apoptotic signaling pathway negative regulation of extrinsic apoptotic signaling pathway via death domain receptors regulation of necroptotic process execution phase of apoptosis toll-like receptor 3 signaling pathway positive regulation of neuron death extrinsic apoptotic signaling pathway via death domain receptors positive regulation of interleukin-1 beta production Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 841 12370 Ensembl ENSG00000064012 ENSMUSG00000026029 UniProt Q14790 O89110 RefSeq (mRNA) NM_001080124 NM_001080125 NM_001228 NM_033355 NM_033356 NM_033357 NM_033358 NM_001372051 NM_001080126 NM_001277926 NM_009812 RefSeq (protein) NP_001073593 NP_001073594 NP_001219 NP_203519 NP_203520 NP_203522 NP_001358980 NP_001073595 NP_001264855 NP_033942 Location (UCSC) Chr 2: 201.23 – 201.29 Mb Chr 1: 58.83 – 58.89 Mb PubMed search [3] [4]
Wikidata
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Caspase-8 is a caspase protein, encoded by the CASP8 gene. It most likely acts upon caspase-3. CASP8 orthologs^[5] have been identified in numerous mammals for which complete genome data are available. These unique orthologs are also present in birds.