Catabolite repression

Carbon catabolite repression, or simply catabolite repression, is an important part of global control system of various bacteria and other microorganisms. Catabolite repression allows microorganisms to adapt quickly to a preferred (rapidly metabolizable) carbon and energy source first. This is usually achieved through inhibition of synthesis of enzymes involved in catabolism of carbon sources other than the preferred one. The catabolite repression was first shown to be initiated by glucose and therefore sometimes referred to as the glucose effect. However, the term "glucose effect" is actually a misnomer since other carbon sources are known to induce catabolite repression.[citation needed]

It was discovered by Frédéric Diénert in 1900.[1][2] Jacques Monod provides a bibliography of pre-1940 literature.[3]

  1. ^ Diénert, M. Frédéric. Sur la fermentation du galactose et sur l'accoutumance des levures à ce sucre. E. Charaire, 1900. Doctoral Thesis. Published in a short form in Ann. hzst. Pasteur, 14, 139-189.
  2. ^ Blaiseau, Pierre Louis; Holmes, Allyson M. (June 2021). "Diauxic Inhibition: Jacques Monod's Ignored Work". Journal of the History of Biology. 54 (2): 175–196. doi:10.1007/s10739-021-09639-4. ISSN 0022-5010. PMC 8376690. PMID 33977422.
  3. ^ Monod, Jacques (1978), "The phenomenon of enzymatic adaptation And Its Bearings on Problems of Genetics and Cellular Differentiation", Selected Papers in Molecular Biology by Jacques Monod, Elsevier, pp. 68–134, doi:10.1016/b978-0-12-460482-7.50017-8, ISBN 978-0-12-460482-7, retrieved 2024-06-23 Alt URL