Catechol-O-methyltransferase

COMT
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCOMT, HEL-S-98n, catechol-O-methyltransferase
External IDsOMIM: 116790; MGI: 88470; HomoloGene: 30982; GeneCards: COMT; OMA:COMT - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000754
NM_001135161
NM_001135162
NM_007310
NM_001362828

NM_001111062
NM_001111063
NM_007744

RefSeq (protein)

NP_000745
NP_001128633
NP_001128634
NP_009294
NP_001349757

NP_001104532
NP_001104533
NP_031770

Location (UCSC)Chr 22: 19.94 – 19.97 MbChr 16: 18.23 – 18.25 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
catechol-O-methyltransferase
Identifiers
EC no.2.1.1.6
CAS no.9012-25-3
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins
Norepinephrine degradation. Catechol-O-methyltransferase is shown in green boxes.[5][6]

Catechol-O-methyltransferase (COMT; EC 2.1.1.6) is one of several enzymes that degrade catecholamines (neurotransmitters such as dopamine, epinephrine, and norepinephrine), catecholestrogens, and various drugs and substances having a catechol structure.[7] In humans, catechol-O-methyltransferase protein is encoded by the COMT gene.[8] Two isoforms of COMT are produced: the soluble short form (S-COMT) and the membrane bound long form (MB-COMT). As the regulation of catecholamines is impaired in a number of medical conditions, several pharmaceutical drugs target COMT to alter its activity and therefore the availability of catecholamines.[9] COMT was first discovered by the biochemist Julius Axelrod in 1957.[10]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000093010Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000000326Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Flower R, Rang HP, Dale MM, Ritter JM (2007). "Figure 11-4". Rang & Dale's pharmacology (6th ed.). Edinburgh: Churchill Livingstone. ISBN 978-0-443-06911-6.
  6. ^ Rang HP, Dale MM, Ritter JM, Flower RJ, Henderson G (2011). "Figure 14.4". Rang & Dale's Pharmacology. Student consult (7th ed.). Elsevier Health Sciences. ISBN 978-0-7020-4504-2.
  7. ^ "Test ID: COMT: Catechol-O-Methyltransferase Genotype". mayomedicallaboratories.com. Mayo Clinic: Mayo Medical Laboratories. Archived from the original on September 18, 2008. Retrieved November 16, 2016.
  8. ^ Grossman MH, Emanuel BS, Budarf ML (April 1992). "Chromosomal mapping of the human catechol-O-methyltransferase gene to 22q11.1----q11.2". Genomics. 12 (4): 822–825. doi:10.1016/0888-7543(92)90316-K. PMID 1572656.
  9. ^ Tai CH, Wu RM (February 2002). "catechol-O-methyltransferase and Parkinson's disease". Acta Medica Okayama. 56 (1): 1–6. doi:10.18926/AMO/31725. PMID 11873938.
  10. ^ Axelrod J (August 1957). "O-methylation of epinephrine and other catechols in vitro and in vivo". Science. 126 (3270): 400–401. Bibcode:1957Sci...126..400A. doi:10.1126/science.126.3270.400. PMID 13467217.