Cathepsin C

CTSC
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4OEM, 1K3B, 2DJF, 2DJG, 3PDF, 4CDC, 4CDD, 4CDE, 4CDF, 4OEL
Identifiers
Aliases	CTSC, CPPI, DPP-I, DPP1, DPPI, HMS, JP, JPD, PALS, PDON1, PLS, cathepsin C
External IDs	OMIM: 602365; MGI: 109553; HomoloGene: 1373; GeneCards: CTSC; OMA:CTSC - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q14.2 Start 88,265,069 bp[1] End 88,359,684 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 D3 Start 87,927,293 bp[2] End 87,960,096 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in palpebral conjunctiva epithelium of nasopharynx stromal cell of endometrium gallbladder appendix bronchial epithelial cell lymph node rectum monocyte granulocyte Top expressed in left lung lobe right lung lobe hair follicle stroma of bone marrow carotid body yolk sac parotid gland primitive streak ciliary body conjunctival fornix More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase activator activity involved in apoptotic process phosphatase binding cysteine-type peptidase activity chaperone binding protein self-association peptidase activity protein binding identical protein binding chloride ion binding cysteine-type endopeptidase activity serine-type endopeptidase activity hydrolase activity Cellular component Golgi apparatus endoplasmic reticulum lumen membrane endoplasmic reticulum COPII-coated ER to Golgi transport vesicle lysosome extracellular exosome endoplasmic reticulum-Golgi intermediate compartment membrane Golgi membrane extracellular region extracellular space nucleoplasm centrosome azurophil granule lumen intracellular membrane-bounded organelle collagen-containing extracellular matrix cytoplasm Biological process ageing positive regulation of proteolysis involved in cellular protein catabolic process positive regulation of apoptotic signaling pathway response to organic substance proteolysis endoplasmic reticulum to Golgi vesicle-mediated transport COPII vesicle coating immune response proteolysis involved in cellular protein catabolic process T cell mediated cytotoxicity apoptotic process neutrophil degranulation negative regulation of myelination positive regulation of microglial cell activation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1075 13032 Ensembl ENSG00000109861 ENSMUSG00000030560 UniProt P53634 P97821 RefSeq (mRNA) NM_148170 NM_001114173 NM_001814 NM_009982 NM_001311790 RefSeq (protein) NP_001107645 NP_001805 NP_680475 NP_001298719 NP_034112 Location (UCSC) Chr 11: 88.27 – 88.36 Mb Chr 7: 87.93 – 87.96 Mb PubMed search [3] [4]
Wikidata
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Cathepsin C exclusion domain
re-determination of the native structure of human dipeptidyl peptidase i (cathepsin c)
Identifiers
Symbol	CathepsinC_exc
Pfam	PF08773
InterPro	IPR014882
SCOP2	1k3b / SCOPe / SUPFAM
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Cathepsin C (CTSC) also known as dipeptidyl peptidase I (DPP-I) is a lysosomal exo-cysteine protease belonging to the peptidase C1 protein family, a subgroup of the cysteine cathepsins. In humans, it is encoded by the CTSC gene.^[5][6]