Cathepsin G

CTSG
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCTSG, CATG, CG, cathepsin G
External IDsOMIM: 116830; MGI: 88563; HomoloGene: 105646; GeneCards: CTSG; OMA:CTSG - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001911

NM_007800

RefSeq (protein)

NP_001902

NP_031826

Location (UCSC)Chr 14: 24.57 – 24.58 MbChr 14: 56.34 – 56.34 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cathepsin G is a protein that in humans is encoded by the CTSG gene. It is one of the three serine proteases of the chymotrypsin family that are stored in the azurophil granules, and also a member of the peptidase S1 protein family. Cathepsin G plays an important role in eliminating intracellular pathogens and breaking down tissues at inflammatory sites, as well as in anti-inflammatory response.[5][6][7][8]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000100448Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040314Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Janoff A, Scherer J (November 1968). "Mediators of inflammation in leukocyte lysosomes. IX. Elastinolytic activity in granules of human polymorphonuclear leukocytes". The Journal of Experimental Medicine. 128 (5): 1137–55. doi:10.1084/jem.128.5.1137. PMC 2138566. PMID 5303065.
  6. ^ Kao RC, Wehner NG, Skubitz KM, Gray BH, Hoidal JR (December 1988). "Proteinase 3. A distinct human polymorphonuclear leukocyte proteinase that produces emphysema in hamsters". The Journal of Clinical Investigation. 82 (6): 1963–73. doi:10.1172/JCI113816. PMC 442778. PMID 3198760.
  7. ^ Baggiolini M, Schnyder J, Bretz U, Dewald B, Ruch W (1979). "Cellular Mechanisms of Proteinase Release from Inflammatory Cells and the Degradation of Extracellular Proteins". In Evered D, Whelan J (eds.). Ciba Foundation Symposium 75 - Protein Degradation in Health and Disease. Novartis Foundation Symposia. Vol. 75. pp. 105–21. doi:10.1002/9780470720585.ch7. ISBN 9780470720585. PMID 399884.
  8. ^ Virca GD, Metz G, Schnebli HP (October 1984). "Similarities between human and rat leukocyte elastase and cathepsin G". European Journal of Biochemistry. 144 (1): 1–9. doi:10.1111/j.1432-1033.1984.tb08423.x. PMID 6566611.