In the fields of biochemistry and cell biology, the cation-dependent mannose-6-phosphate receptor (CD-MPR) also known as the 46 kDa mannose 6-phosphate receptor is a protein that in humans is encoded by the M6PR gene.[5][6]
The CD-MPR is one of two transmembrane proteins that bind mannose-6-phosphate (M6P) tags on acid hydrolase precursors in the Golgi apparatus that are destined for transport to the lysosome. Homologues of CD-MPR are found in all eukaryotes.
- ^ a b c GRCh38: Ensembl release 89: ENSG00000003056 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000007458 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Dahms NM, Lobel P, Breitmeyer J, Chirgwin JM, Kornfeld S (July 1987). "46 kd mannose 6-phosphate receptor: cloning, expression, and homology to the 215 kd mannose 6-phosphate receptor". Cell. 50 (2): 181–92. doi:10.1016/0092-8674(87)90214-5. PMID 2954652. S2CID 23842311.
- ^ Pohlmann R, Nagel G, Schmidt B, Stein M, Lorkowski G, Krentler C, Cully J, Meyer HE, Grzeschik KH, Mersmann G (August 1987). "Cloning of a cDNA encoding the human cation-dependent mannose 6-phosphate-specific receptor". Proc. Natl. Acad. Sci. U.S.A. 84 (16): 5575–9. Bibcode:1987PNAS...84.5575P. doi:10.1073/pnas.84.16.5575. PMC 298905. PMID 2441386.