Cattaraugus Reservation is an Indian reservation located partly in Cattaraugus County, New York, United States. The population was 314 at the 2010 census. The majority of the residents are of the federally recognized Seneca Nation, one of the original Five Nations of the Iroquois Confederacy.
The majority of the reservation is in Erie County and smaller portions are located in Cattaraugus County and Chautauqua County. The main population center in this portion of the reservation is Versailles, which straddles the southern border of the reservation.