Cav1.1

CACNA1S
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2VAY
Identifiers
Aliases	CACNA1S, CACNL1A3, CCHL1A3, Cav1.1, HOKPP, HOKPP1, MHS5, TTPP1, hypoPP, calcium voltage-gated channel subunit alpha1 S, DHPR
External IDs	OMIM: 114208; MGI: 88294; HomoloGene: 37257; GeneCards: CACNA1S; OMA:CACNA1S - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q32.1 Start 201,039,512 bp[1] End 201,112,451 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 E4|1 59.55 cM Start 135,980,488 bp[2] End 136,047,560 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in glutes muscle of thigh triceps brachii muscle vastus lateralis muscle Skeletal muscle tissue of rectus abdominis thoracic diaphragm Skeletal muscle tissue of biceps brachii gastrocnemius muscle deltoid muscle tibialis anterior muscle Top expressed in muscle of thigh extensor digitorum longus muscle plantaris muscle triceps brachii muscle ankle medial head of gastrocnemius muscle temporal muscle sternocleidomastoid muscle quadriceps femoris muscle skeletal muscle tissue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function voltage-gated calcium channel activity calcium channel activity metal ion binding voltage-gated ion channel activity high voltage-gated calcium channel activity ion channel activity protein binding calmodulin binding Cellular component cytoplasm voltage-gated calcium channel complex integral component of membrane membrane I band T-tubule L-type voltage-gated calcium channel complex plasma membrane sarcolemma Biological process muscle contraction membrane depolarization during action potential regulation of ion transmembrane transport ion transport calcium ion transmembrane transport transmembrane transport calcium ion transport cellular response to caffeine calcium ion import cardiac conduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 779 12292 Ensembl ENSG00000081248 ENSMUSG00000026407 UniProt Q13698 Q02789 RefSeq (mRNA) NM_000069 NM_001081023 NM_014193 RefSeq (protein) NP_000060 NP_001074492 NP_055008 NP_001389878 Location (UCSC) Chr 1: 201.04 – 201.11 Mb Chr 1: 135.98 – 136.05 Mb PubMed search [3] [4]
Wikidata
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Ca_v1.1 also known as the calcium channel, voltage-dependent, L type, alpha 1S subunit, (CACNA1S), is a protein which in humans is encoded by the CACNA1S gene.^[5] It is also known as CACNL1A3 and the dihydropyridine receptor (DHPR, so named due to the blocking action DHP has on it).