Cdc25

M-phase inducer phosphatase
Identifiers
Aliases	Cdc25 phosphatase
External IDs	OMIM: 157680; GeneCards: [1]; OMA:- orthologs
Orthologs
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	Wikidata
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Cdc25 is a dual-specificity phosphatase first isolated from the yeast Schizosaccharomyces pombe as a cell cycle defective mutant.^[1] As with other cell cycle proteins or genes such as Cdc2 and Cdc4, the "cdc" in its name refers to "cell division cycle".^[2] Dual-specificity phosphatases are considered a sub-class of protein tyrosine phosphatases. By removing inhibitory phosphate residues from target cyclin-dependent kinases (Cdks),^[3] Cdc25 proteins control entry into and progression through various phases of the cell cycle, including mitosis and S ("Synthesis") phase.

^ cdc25+ functions as an inducer in the mitotic control of fission yeast. Russell P, Nurse P. (1986 ) Cell: 45:145-53
^ Boutros, R., Lobjois, V. & Ducommun, B. CDC25 phosphatases in cancer cells: key players? Good targets?. Nat Rev Cancer 7, 495–507 (2007). https://doi.org/10.1038/nrc2169
^ Strausfeld U, Labbé JC, Fesquet D, et al. (May 1991). "Dephosphorylation and activation of a p34cdc2/cyclin B complex in vitro by human CDC25 protein". Nature. 351 (6323): 242–5. Bibcode:1991Natur.351..242S. doi:10.1038/351242a0. PMID 1828290. S2CID 4372756.

[1] 25+ functions as an inducer in the mitotic control of fission yeast. Russell P, Nurse P. (1986 ) Cell: 45:145-53

[2] Boutros, R., Lobjois, V. & Ducommun, B. CDC25 phosphatases in cancer cells: key players? Good targets?. Nat Rev Cancer 7, 495–507 (2007). https://doi.org/10.1038/nrc2169

[3] Strausfeld U, Labbé JC, Fesquet D, et al. (May 1991). "Dephosphorylation and activation of a p34cdc2/cyclin B complex in vitro by human CDC25 protein". Nature. 351 (6323): 242–5. Bibcode:1991Natur.351..242S. doi:10.1038/351242a0. PMID 1828290. S2CID 4372756.

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