Orc1/Cdc6-type DNA replication protein, archaea Crystal Structure of CDC6 from
P. aerophilum (
PDB : 1FNN ). Green and blue domains are
AAA domains ; red domain is the Cdc6 C-terminal HTH domain (infobox below).
[ 1] Symbol Orc1/Cdc6_arc InterPro IPR014277
Cdc6 , or cell division cycle 6 , is a protein in eukaryotic cells. It is mainly studied in the budding yeast Saccharomyces cerevisiae P09119 DNA replication and plays important roles in the activation and maintenance of the checkpoint mechanisms in the cell cycle that coordinate S phase and mitosis . It is part of the pre-replicative complex (pre-RC) and is required for loading minichromosome maintenance (MCM) proteins onto the DNA, an essential step in the initiation of DNA synthesis. In addition, it is a member of the family of AAA+ ATPases and highly related to ORC1 ; both are the same protein in archaea .[ 2]
