Cefodizime

Cefodizime
Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	J01DD09 (WHO) ;
Identifiers
	IUPAC name (6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-; methoxyiminoacetyl]amino}-3-{[5-(carboxymethyl)-; 4-methyl-1,3-thiazol-2-yl]sulfanylmethyl}-8-oxo-; 5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;
CAS Number	69739-16-8 ;
PubChem CID	5361871;
ChemSpider	4514859 ;
UNII	Z31298J4HQ;
KEGG	D07643 ;
ChEMBL	ChEMBL1161746 ;
CompTox Dashboard (EPA)	DTXSID2022757 ;
ECHA InfoCard	100.148.965
Chemical and physical data
Formula	C20H20N6O7S4
Molar mass	584.66 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C2N1/C(=C(\CS[C@@H]1[C@@H]2NC(=O)C(=N\OC)/c3nc(sc3)N)CSc4nc(c(s4)CC(=O)O)C)C(=O)O;
	InChI InChI=1S/C20H20N6O7S4/c1-7-10(3-11(27)28)37-20(22-7)36-5-8-4-34-17-13(16(30)26(17)14(8)18(31)32)24-15(29)12(25-33-2)9-6-35-19(21)23-9/h6,13,17H,3-5H2,1-2H3,(H2,21,23)(H,24,29)(H,27,28)(H,31,32)/b25-12-/t13-,17-/m1/s1 ; Key:XDZKBRJLTGRPSS-BGZQYGJUSA-N ;
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Cefodizime is a 3rd generation cephalosporin antibiotic with broad spectrum activity against aerobic gram positive and gram negative bacteria. Clinically, it has been shown to be effective against upper and lower respiratory tract infections, urinary tract infections, and gonorrhea. Cefodizime is a bactericidal antibiotic that targets penicillin-binding proteins (PBPs) 1A/B, 2, and 3 resulting in the eventual death of the bacterial cell. In vivo experimental models of infection showed that bacterial clearance by this drug is at least as effective compared with other 3rd generation cephalosporins. It has similar adverse effect profile to other 3rd generation cephalosporins as well, mainly being limited to gastrointestinal or dermatological side effects.^[1]

It is not currently approved by the FDA for use in the United States.

^ Barradell LB, Brogden RN (November 1992). "Cefodizime. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use". Drugs. 44 (5): 800–34. doi:10.2165/00003495-199244050-00008. PMID 1280568. S2CID 195697050.

[Barradell-1] Barradell LB, Brogden RN (November 1992). "Cefodizime. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use". Drugs. 44 (5): 800–34. doi:10.2165/00003495-199244050-00008. PMID 1280568. S2CID 195697050.

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