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| Combination of | |
|---|---|
| Ceftazidime | Cephalosporin antibiotic |
| Avibactam | β-lactamase inhibitor |
| Clinical data | |
| Trade names | Avycaz, Zavicefta, others[1] |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a615018 |
| License data | |
| Pregnancy category |
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| Routes of administration | Intravenous infusion |
| ATC code | |
| Legal status | |
| Legal status | |
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| PubChem CID | |
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Ceftazidime/avibactam, sold under the brand name Avycaz (by AbbVie) among others, is a fixed-dose combination medication composed of ceftazidime, a cephalosporin antibiotic, and avibactam, a β-lactamase inhibitor.[4] It is used to treat complicated intra-abdominal infections, urinary tract infections, and pneumonia.[4][5] It is only recommended when other options are not appropriate.[4] It is given by infusion into a vein.[4]
Common side effect include nausea, fever, liver problems, headache, trouble sleeping, and pain at the site of infusion.[4] Severe side effects may include anaphylaxis, seizures, and Clostridioides difficile-associated diarrhea.[4] While use appears to be safe in pregnancy the medication has not been well studied in this group.[6] Doses should be adjusted in those with kidney problems.[7] Ceftazidime works by interfering with the building of the bacterial cell wall while avibactam works by preventing ceftazidime's breakdown.[4]
The combination was approved for medical use in the United States and the European Union in 2015.[4][5] It is on the World Health Organization's List of Essential Medicines.[8] Resistances are increasingly been reported with United States, Greece and Italy accounting for 80% of cases.[9]
- ^ "Briefing package: ceftazidime-avibactam. Anti-infective drugs advisory committee meeting" (PDF). U.S. Food and Drug Administration (FDA). Archived from the original (PDF) on 30 June 2015. Retrieved 27 June 2015.
- ^ "Avycaz- ceftazidime, avibactam powder, for solution". DailyMed. 26 January 2024. Retrieved 21 February 2024.
- ^ "Zavicefta EPAR". European Medicines Agency. 23 June 2016. Retrieved 21 February 2024.
- ^ a b c d e f g h "Ceftazidime and Avibactam Sodium Monograph for Professionals". Drugs.com. Retrieved 25 October 2019.
- ^ a b "Application for inclusion of ceftazidime-avibactam" (PDF). WHO. Retrieved 25 October 2019.
- ^ "Avibactam / ceftazidime (Avycaz) Use During Pregnancy". Drugs.com. Retrieved 25 October 2019.
- ^ Mosley JF, Smith LL, Parke CK, Brown JA, Wilson AL, Gibbs LV (August 2016). "Ceftazidime-Avibactam (Avycaz): For the Treatment of Complicated Intra-Abdominal and Urinary Tract Infections". P & T. 41 (8): 479–483. PMC 4959616. PMID 27504064.
- ^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
- ^ Di Bella S, Giacobbe DR, Maraolo AE, Viaggi V, Luzzati R, Bassetti M, et al. (June 2021). "Resistance to ceftazidime/avibactam in infections and colonisations by KPC-producing Enterobacterales: a systematic review of observational clinical studies". Journal of Global Antimicrobial Resistance. 25: 268–281. doi:10.1016/j.jgar.2021.04.001. hdl:11368/2990131. PMID 33895414. S2CID 233399477.