Cell adhesion

Schematic of cell adhesion

Cell adhesion is the process by which cells interact and attach to neighbouring cells through specialised molecules of the cell surface. This process can occur either through direct contact between cell surfaces such as cell junctions or indirect interaction, where cells attach to surrounding extracellular matrix, a gel-like structure containing molecules released by cells into spaces between them.[1] Cells adhesion occurs from the interactions between cell-adhesion molecules (CAMs),[2] transmembrane proteins located on the cell surface. Cell adhesion links cells in different ways and can be involved in signal transduction for cells to detect and respond to changes in the surroundings.[1][3] Other cellular processes regulated by cell adhesion include cell migration and tissue development in multicellular organisms.[4] Alterations in cell adhesion can disrupt important cellular processes and lead to a variety of diseases, including cancer[5][6] and arthritis.[7] Cell adhesion is also essential for infectious organisms, such as bacteria or viruses, to cause diseases.[8][9]

  1. ^ a b Alberts, Bruce; Johnson, Alexander; Lewis, Julian; Morgan, David; Raff, Martin; Roberts, Keith; Walter, Peter (2014). Molecular Biology of the Cell (6th ed.). Garland Science. ISBN 9780815344322.
  2. ^ Lodish, Harvey; Berk, Arnold; Matsudaira, Paul; Kaiser, Chris A.; Krieger, Monty; Scott, Matthew P.; Zipursky, Lawrence; Darnell, James (2003). Molecular Cell Biology (5th ed.). W.H. Freeman. ISBN 978-0716743668.
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  4. ^ Sumigray, Kaelyn D.; Lechler, Terry (2015). Cell Adhesion in Epidermal Development and Barrier Formation. Vol. 112. pp. 383–414. doi:10.1016/bs.ctdb.2014.11.027. ISBN 9780124077584. PMC 4737682. PMID 25733147. {{cite book}}: |journal= ignored (help)
  5. ^ Okegawa, T; Pong, RC; Li, Y; Hsieh, JT (2004). "The role of cell adhesion molecule in cancer progression and its application in cancer therapy". Acta Biochimica Polonica. 51 (2): 445–57. doi:10.18388/abp.2004_3583. PMID 15218541.
  6. ^ Hirohashi, Setsuo; Kanai, Yae (2003). "Cell adhesion system and human cancer morphogenesis". Cancer Science. 94 (7): 575–581. doi:10.1111/j.1349-7006.2003.tb01485.x. PMC 11160151. PMID 12841864. S2CID 22154824.
  7. ^ Szekanecz, Zoltan; Koch, Alisa E (2000). "Cell–cell interactions in synovitis: Endothelial cells and immune cell migration". Arthritis Research. 2 (5): 368–373. doi:10.1186/ar114. PMC 130138. PMID 11094450.
  8. ^ Pizarro-Cerdá, Javier; Cossart, Pascale (2006). "Bacterial Adhesion and Entry into Host Cells". Cell. 124 (4): 715–727. doi:10.1016/j.cell.2006.02.012. PMID 16497583. S2CID 5769387.
  9. ^ Mateo, M.; Generous, A.; Sinn, P. L.; Cattaneo, R. (2015). "Connections matter - how viruses use cellcell adhesion components". Journal of Cell Science. 128 (3): 431–439. doi:10.1242/jcs.159400. PMC 4311127. PMID 26046138.