Cerebroprotectant

A cerebroprotectant (formerly known as a neuroprotectant) is a drug that is intended to protect the brain after the onset of acute ischemic stroke.[1] As stroke is the second largest cause of death worldwide and a leading cause of adult disability, over 150 drugs have been tested in clinical trials to provide cerebroprotection.[2][3][4]

  1. ^ Lyden P, Buchan A, Boltze J, Fisher M (August 2021). "Top Priorities for Cerebroprotective Studies-A Paradigm Shift: Report From STAIR XI". Stroke. 52 (9): 3063–3071. doi:10.1161/STROKEAHA.121.034947. PMC 8384700. PMID 34289707.
  2. ^ World Health Organization. "The top 10 causes of death". Retrieved 11 May 2022.
  3. ^ Virani SS, Alonso A, Benjamin EJ, Bittencourt MS, Callaway CW, Carson AP, et al. (American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee) (March 2020). "Heart Disease and Stroke Statistics-2020 Update: A Report From the American Heart Association". Circulation. 141 (9): e139–e596. doi:10.1161/CIR.0000000000000757. PMID 31992061. S2CID 210949245.
  4. ^ O'Collins VE, Macleod MR, Donnan GA, Horky LL, van der Worp BH, Howells DW (March 2006). "1,026 experimental treatments in acute stroke". Annals of Neurology. 59 (3): 467–477. doi:10.1002/ana.20741. PMID 16453316. S2CID 42939489.