Mammalian protein found in Homo sapiens
Ceruloplasmin (or caeruloplasmin ) is a ferroxidase enzyme that in humans is encoded by the CP gene .[ 5] [ 6] [ 7]
Ceruloplasmin is the major copper -carrying protein in the blood, and in addition plays a role in iron metabolism . It was first described in 1948.[ 8] hephaestin , is noted for its homology to ceruloplasmin, and also participates in iron and probably copper metabolism.
^ a b c GRCh38: Ensembl release 89: ENSG00000047457 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000003617 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Takahashi N, Ortel TL, Putnam FW (Jan 1984). "Single-chain structure of human ceruloplasmin: the complete amino acid sequence of the whole molecule" . Proceedings of the National Academy of Sciences of the United States of America . 81 (2): 390–4. Bibcode :1984PNAS...81..390T . doi :10.1073/pnas.81.2.390 PMC 344682 PMID 6582496 . ^ Koschinsky ML , Funk WD, van Oost BA, MacGillivray RT (Jul 1986). "Complete cDNA sequence of human preceruloplasmin" . Proceedings of the National Academy of Sciences of the United States of America . 83 (14): 5086–90. Bibcode :1986PNAS...83.5086K . doi :10.1073/pnas.83.14.5086 PMC 323895 PMID 2873574 .^ Royle NJ, Irwin DM, Koschinsky ML, MacGillivray RT, Hamerton JL (May 1987). "Human genes encoding prothrombin and ceruloplasmin map to 11p11-q12 and 3q21-24, respectively". Somatic Cell and Molecular Genetics . 13 (3): 285–92. doi :10.1007/BF01535211 . PMID 3474786 . S2CID 45686258 . ^ Holmberg CG, Laurell CB (1948). "Investigations in serum copper. II. Isolation of the Copper containing protein, and a description of its properties" . Acta Chem Scand . 2 : 550–56. doi :10.3891/acta.chem.scand.02-0550 
