Charalambides (also spelled Charalambidis or Charalampidis) is a Greek surname. It may refer to:
Nora Charles in Dashiel Hammett's 1934 book The Thin Man teasingly calls her detective husband, Nick Charles, "Mr. Charalambides," referencing Nick's earlier explanation that "Charles" is not Greek-sounding because "the Old Man" (either his father or grandfather) acquiesced to changing it upon immigrating to America.