Charged aerosol detector

The charged aerosol detector (CAD) is a detector used in conjunction with high-performance liquid chromatography (HPLC) and ultra high-performance liquid chromatography (UHPLC) to measure the amount of chemicals in a sample by creating charged aerosol particles which are detected using an electrometer.[1][2][3][4] It is commonly used for the analysis of compounds that cannot be detected using traditional UV/Vis approaches due to their lack of a chromophore. The CAD can measure all non-volatile and many semi-volatile analytes including, but not limited to, antibiotics, excipients, ions, lipids, natural products, biofuels, sugars and surfactants.[4] The CAD, like other aerosol detectors (e.g., evaporative light scattering detectors (ELSD) and condensation nucleation light scattering detectors (CNLSD)), falls under the category of destructive general-purpose detectors (see Chromatography detectors).

  1. ^ Gamache P. (2005) HPLC analysis of nonvolatile analytes using charged aerosol detection retrieved September 17, 2015.
  2. ^ "Dionex - Charged Aerosol Detectors". www.dionex.com. Retrieved 2016-01-21.
  3. ^ Vehovec, Tanja; Obreza, Aleš (2010-03-05). "Review of operating principle and applications of the charged aerosol detector". Journal of Chromatography A. 1217 (10): 1549–1556. doi:10.1016/j.chroma.2010.01.007. PMID 20083252.
  4. ^ a b Acworth, Ian N.; Kopaciewicz, William (2017). Gamache, Paul H. (ed.). Charged Aerosol Detection for Liquid Chromatography and Related Separation Techniques. John Wiley & Sons, Inc. pp. 67–162. doi:10.1002/9781119390725.ch2. ISBN 9781119390725.