Charles Griffin (1825–1867) was a U.S. Army officer and Union general.
Charles or Charlie Griffin may also refer to:
- Charles A. Griffin (born 1884), American politician
- Charles Griffin (baseball) (fl. 1887), American baseball player
- Charles Griffin (Hudson's Bay Company), person involved in the Pig War
- Charles D. Griffin (1906–1996), U.S. Navy admiral
- Charles H. Griffin (1926–1989), U.S. Representative from Mississippi
- Charlie Griffin (born 1979), English footballer
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