Charles Sweeney (1837–?), Confederate soldier who owned the Charles Sweeney Cabin, Appomattox Court House National Historical Park, Virginia, United States, in which General Fitzhugh Lee and his staff may have spent the night before Robert E. Lee's surrender to Ulysses S. Grant
Charlie Sweeney (1863–1902), American Major League Baseball pitcher
Charles Sweeny (1882–1963), American officer in several nations' militaries and soldier of fortune
Buck Sweeney (1890–1955), American baseball player
Charles Francis Sweeny (1909 or 1910–1993), American businessman instrumental in forming the Second World War Eagle Squadrons, nephew of the soldier of fortune
Charles Sweeney (1919–2004), United States Air Force major general who piloted the bomber that dropped the second atomic bomb in World War II
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