Charles Thomas Pearce (1815–1883) M.D., M.R.C.S., F.R.S., was an English physician and early opponent of mandatory vaccination. A member of the Royal College of Surgeons, fellow of the Royal Society and a Freemason, Charles was a homoeopath and surgeon, with an interest in medical astrology, vegetarianism, improved care for the mentally ill and the cessation of vivisection.