| Charybdotoxin | |||||||
|---|---|---|---|---|---|---|---|
 | |||||||
| Identifiers | |||||||
| Organism | |||||||
| Symbol | ChTX | ||||||
| Alt. symbols | ChTX-Lq1, ChTx-a | ||||||
| CAS number | 95751-30-7 | ||||||
| PDB | 2crd More structures | ||||||
| UniProt | P13487 | ||||||
| |||||||
Charybdotoxin (ChTX) is a 37 amino acid neurotoxin from the venom of the scorpion Leiurus quinquestriatus hebraeus (deathstalker) that blocks calcium-activated potassium channels.[2] This blockade causes hyperexcitability of the nervous system. It is a close homologue of agitoxin and both toxins come from Leiurus quinquestriatus hebraeus. It is named after Charybdis, a sea monster from Greek myth.[3]
- ^ Ben-Tal N, Honig B, Miller C, McLaughlin S (October 1997). "Electrostatic binding of proteins to membranes. Theoretical predictions and experimental results with charybdotoxin and phospholipid vesicles". Biophys. J. 73 (4): 1717–27. Bibcode:1997BpJ....73.1717B. doi:10.1016/S0006-3495(97)78203-1. PMC 1181073. PMID 9336168.
- ^ Laurent F, Michel A, Bonnet PA, Chapat JP, Boucard M (March 1993). "Evaluation of the relaxant effects of SCA40, a novel charybdotoxin-sensitive potassium channel opener, in guinea-pig isolated trachealis". Br. J. Pharmacol. 108 (3): 622–6. doi:10.1111/j.1476-5381.1993.tb12851.x. PMC 1908044. PMID 7682131.
- ^ Senning A (2006-10-30). Elsevier's Dictionary of Chemoetymology: The Whys and Whences of Chemical Nomenclature and Terminology. Elsevier. ISBN 978-0-08-048881-3.