Chemoprophylaxis

Chemoprevention or chemoprophylaxis refers to the administration of a medication for the purpose of preventing disease or infection.[1] [2] Antibiotics, for example, may be administered to patients with disorders of immune system function to prevent bacterial infections (particularly opportunistic infection).[3] Antibiotics may also be administered to healthy individuals to limit the spread of an epidemic, or to patients who have repeated infections (such as urinary tract infections) to prevent recurrence. It may also refer to the administration of heparin to prevent deep venous thrombosis in hospitalized patients.

In some cases, chemoprophylaxis is initiated to prevent the spread of an existing infection in an individual to a new organ system, as when intrathecal chemotherapy is administered in patients with malignancy to prevent further infection.

The use of chemoprophylaxis is limited primarily by two factors: risk and financial costs.

  • All medications have the potential to cause side effects. In general, chemoprophylaxis should be initiated only when the benefits of treatment outweigh the risks.
  • The cost associated with chemoprophylaxis may be prohibitive, particularly when the cost of treatment is high or the incidence of the target disease is low. Many forms of chemoprophylaxis are therefore not cost-effective.
  1. ^ Cite error: The named reference Woolf_et_al2008 was invoked but never defined (see the help page).
  2. ^ Fahey, Jed W.; Kensler, Thomas W. (2013-04-01). "Health Span Extension through Green Chemoprevention". AMA Journal of Ethics. 15 (4): 311–318. doi:10.1001/virtualmentor.2013.15.4.stas1-1304. ISSN 2376-6980.
  3. ^ Cite error: The named reference Golan2008 was invoked but never defined (see the help page).