Chlordane

Chlordane
cis-chlordane (α-chlordane)
trans-chlordane (γ-chlordane, beta-chlordane)
cis-chlordane
trans-chlordane
Names
Systematic IUPAC name
1,2,4,5,6,7,8,8-Octachloro-3a,4,7,7a-tetrahydro-4,7-methanoindane
Other names
Chlordan; Chlordano; Ortho; Octachloro-4,7-methanohydroindane
Identifiers
ECHA InfoCard 100.000.317 Edit this at Wikidata
KEGG
UNII
Properties
C10H6Cl8
Molar mass 409.76 g·mol−1
Appearance White solid
Odor Slightly pungent, chlorine-like
Density 1.59 g/cm3
Melting point 102–106 °C (216–223 °F; 375–379 K)[1]
Boiling point decomposes[1]
0.0001% (20°C)[1]
1.565
Hazards
Occupational safety and health (OHS/OSH):
Main hazards
moderately toxic and a suspected human carcinogen
GHS labelling:
GHS06: ToxicGHS08: Health hazardGHS09: Environmental hazard
Danger
H301, H311, H351, H410
P201, P273, P280, P301+P310+P330, P302+P352+P312[2]
Flash point 107 °C (225 °F; 380 K) (open cup)
Explosive limits 0.7–5%
Lethal dose or concentration (LD, LC):
590 mg/kg (rat, oral)
100 mg/kg (rabbit, oral)
430 mg/kg (mouse, oral)
300 mg/kg (rabbit, oral)
145 mg/kg (mouse, oral)
1720 mg/kg (hamster, oral)
200 mg/kg (rat, oral)[3]
NIOSH (US health exposure limits):
PEL (Permissible)
TWA 0.5 mg/m3 [skin][1]
REL (Recommended)
Ca TWA 0.5 mg/m3 [skin][1]
IDLH (Immediate danger)
100 mg/m3[1]
Safety data sheet (SDS) Chlordane (technical mixture)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Chlordane, or chlordan, is an organochlorine compound that was used as a pesticide. It is a white solid. In the United States, chlordane was used for termite-treatment of approximately 30 million homes until it was banned in 1988.[4] Chlordane was banned 10 years earlier for food crops like corn and citrus, and on lawns and domestic gardens.[5]

Like other chlorinated cyclodiene insecticides, chlordane is classified as an organic pollutant hazardous for human health. It is resistant to degradation in the environment and in humans/animals and readily accumulates in lipids (fats) of humans and animals.[6] Exposure to the compound has been linked to cancers, diabetes, and neurological disorders.

  1. ^ a b c d e f NIOSH Pocket Guide to Chemical Hazards. "#0112". National Institute for Occupational Safety and Health (NIOSH).
  2. ^ Sigma-Aldrich Co., Chlordane (technical mixture). Retrieved on 2022-03-17.
  3. ^ "Chlordane". Immediately Dangerous to Life or Health Concentrations (IDLH). National Institute for Occupational Safety and Health (NIOSH).
  4. ^ Toxicological Profile for Chlordane, U.S. Department Of Health and Human Services, Agency for Toxic Substances and Disease Registry
  5. ^ Robert L. Metcalf "Insect Control" in Ullmann’s Encyclopedia of Industrial Chemistry, Wiley-VCH, Weinheim, 2002. doi:10.1002/14356007.a14_263
  6. ^ Agency for Toxic Substances & Disease Registry (ATSDR). Toxic Substances Portal: Chlordane. Last updated September, 2010 [online]. Available at URL: https://wwwn.cdc.gov/TSP/index.aspx?toxid=62