Chloride shift (also known as the Hamburger phenomenon or lineas phenomenon, named after Hartog Jakob Hamburger) is a process which occurs in a cardiovascular system and refers to the exchange of bicarbonate (HCO3−) and chloride (Cl−) across the membrane of red blood cells (RBCs).[1]
- ^ Crandall ED, Mathew SJ, Fleischer RS, Winter HI, Bidani A (1981). "Effects of inhibition of RBC HCO3−/Cl− exchange on CO2 excretion and downstream pH disequilibrium in isolated rat lungs". J. Clin. Invest. 68 (4): 853–62. doi:10.1172/JCI110340. PMC 370872. PMID 6793631.