Clinical data | |
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Trade names | Diuril, others |
Other names | 6-Chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide-1,1-dioxide |
AHFS/Drugs.com | Monograph |
MedlinePlus | a682341 |
Routes of administration | By mouth, IV |
ATC code | |
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Pharmacokinetic data | |
Bioavailability | low |
Metabolism | Nil |
Elimination half-life | 45 to 120 minutes |
Excretion | Renal |
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CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.000.368 |
Chemical and physical data | |
Formula | C7H6ClN3O4S2 |
Molar mass | 295.71 g·mol−1 |
3D model (JSmol) | |
Melting point | 342.5–343 °C (648.5–649.4 °F) |
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Chlorothiazide, sold under the brand name Diuril among others, is an organic compound used as a diuretic and as an antihypertensive.[1][2]
It is used both within the hospital setting or for personal use to manage excess fluid associated with congestive heart failure. Most often taken in pill form, it is usually taken orally once or twice a day. In the ICU setting, chlorothiazide is given to diurese a patient in addition to furosemide (Lasix). Working in a separate mechanism from furosemide and absorbed enterically as a reconstituted suspension administered through a nasogastric tube (NG tube), the two drugs potentiate one another.
It was patented in 1956 and approved for medical use in 1958.[3] It is on the World Health Organization's List of Essential Medicines.[4]