Cholecystokinin B receptor

CCKBR
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1L4T
Identifiers
Aliases	CCKBR, CCK-B, CCK2R, GASR, cholecystokinin B receptor
External IDs	OMIM: 118445; MGI: 99479; HomoloGene: 7258; GeneCards: CCKBR; OMA:CCKBR - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	6,272,127 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	105,120,105 bp
RNA expression pattern
	Top expressed in
	Brodmann area 10; ; frontal pole; ; body of stomach; ; paraflocculus of cerebellum; ; right frontal lobe; ; dorsolateral prefrontal cortex; ; cingulate gyrus; ; middle temporal gyrus; ; anterior cingulate cortex; ; Brodmann area 46;
	Top expressed in
	primary motor cortex; ; perirhinal cortex; ; piriform cortex; ; prefrontal cortex; ; entorhinal cortex; ; Ileal epithelium; ; primary visual cortex; ; anterior amygdaloid area; ; superior frontal gyrus; ; inferior colliculus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; 1-phosphatidylinositol-3-kinase regulator activity; protein binding; type B gastrin/cholecystokinin receptor binding; gastrin receptor activity; cholecystokinin receptor activity; peptide hormone binding;
Cellular component	integral component of membrane; membrane; plasma membrane;
Biological process	gastric acid secretion; positive regulation of cytosolic calcium ion concentration; cell surface receptor signaling pathway; positive regulation of cell population proliferation; cell population proliferation; digestive tract development; signal transduction; gland development; regulation of phosphatidylinositol 3-kinase activity; G protein-coupled receptor signaling pathway; phospholipase C-activating G protein-coupled receptor signaling pathway; cholecystokinin signaling pathway; pH reduction;
	Sources:Amigo / QuickGO
Orthologs
	887
	12426
	ENSG00000110148
	ENSMUSG00000030898
	P32239
	P56481
	NM_176875; NM_001318029; NM_001363552
	NM_007627
	NP_001304958; NP_795344; NP_001350481
	NP_031653
	Wikidata
View/Edit Human	View/Edit Mouse

The cholecystokinin B receptor also known as CCKBR or CCK₂ is a protein^[5] that in humans is encoded by the CCKBR gene.^[6]

This gene encodes a G protein-coupled receptor for gastrin and cholecystokinin (CCK),^[7]^[8]^[9] regulatory peptides of the brain and gastrointestinal tract. This protein is a type B gastrin receptor, which has a high affinity for both sulfated and nonsulfated CCK analogs and is found principally in the central nervous system and the gastrointestinal tract. A misspliced transcript variant including an intron has been observed in cells from colorectal and pancreatic tumors.^[10]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000110148 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030898 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Noble F, Roques BP (Jul 1999). "CCK-B receptor: chemistry, molecular biology, biochemistry and pharmacology". Progress in Neurobiology. 58 (4): 349–79. doi:10.1016/S0301-0082(98)00090-2. PMID 10368033. S2CID 24402373.
^ Pisegna JR, de Weerth A, Huppi K, Wank SA (Nov 1992). "Molecular cloning of the human brain and gastric cholecystokinin receptor: structure, functional expression and chromosomal localization". Biochemical and Biophysical Research Communications. 189 (1): 296–303. doi:10.1016/0006-291X(92)91557-7. PMC 6719700. PMID 1280419.
^ Harikumar KG, Clain J, Pinon DI, Dong M, Miller LJ (Jan 2005). "Distinct molecular mechanisms for agonist peptide binding to types A and B cholecystokinin receptors demonstrated using fluorescence spectroscopy". The Journal of Biological Chemistry. 280 (2): 1044–50. doi:10.1074/jbc.M409480200. PMID 15520004.
^ Aloj L, Caracò C, Panico M, Zannetti A, Del Vecchio S, Tesauro D, De Luca S, Arra C, Pedone C, Morelli G, Salvatore M (Mar 2004). "In vitro and in vivo evaluation of 111In-DTPAGlu-G-CCK8 for cholecystokinin-B receptor imaging". Journal of Nuclear Medicine. 45 (3): 485–94. PMID 15001692.
^ Galés C, Poirot M, Taillefer J, Maigret B, Martinez J, Moroder L, Escrieut C, Pradayrol L, Fourmy D, Silvente-Poirot S (May 2003). "Identification of tyrosine 189 and asparagine 358 of the cholecystokinin 2 receptor in direct interaction with the crucial C-terminal amide of cholecystokinin by molecular modeling, site-directed mutagenesis, and structure/affinity studies". Molecular Pharmacology. 63 (5): 973–82. doi:10.1124/mol.63.5.973. PMID 12695525. S2CID 38395309.
^ "Entrez Gene: CCKBR cholecystokinin B receptor".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000110148 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030898 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10368033-5] Noble F, Roques BP (Jul 1999). "CCK-B receptor: chemistry, molecular biology, biochemistry and pharmacology". Progress in Neurobiology. 58 (4): 349–79. doi:10.1016/S0301-0082(98)00090-2. PMID 10368033. S2CID 24402373.

[pmid1280419-6] Pisegna JR, de Weerth A, Huppi K, Wank SA (Nov 1992). "Molecular cloning of the human brain and gastric cholecystokinin receptor: structure, functional expression and chromosomal localization". Biochemical and Biophysical Research Communications. 189 (1): 296–303. doi:10.1016/0006-291X(92)91557-7. PMC 6719700. PMID 1280419.

[pmid15520004-7] Harikumar KG, Clain J, Pinon DI, Dong M, Miller LJ (Jan 2005). "Distinct molecular mechanisms for agonist peptide binding to types A and B cholecystokinin receptors demonstrated using fluorescence spectroscopy". The Journal of Biological Chemistry. 280 (2): 1044–50. doi:10.1074/jbc.M409480200. PMID 15520004.

[pmid15001692-8] Aloj L, Caracò C, Panico M, Zannetti A, Del Vecchio S, Tesauro D, De Luca S, Arra C, Pedone C, Morelli G, Salvatore M (Mar 2004). "In vitro and in vivo evaluation of 111In-DTPAGlu-G-CCK8 for cholecystokinin-B receptor imaging". Journal of Nuclear Medicine. 45 (3): 485–94. PMID 15001692.

[pmid12695525-9] Galés C, Poirot M, Taillefer J, Maigret B, Martinez J, Moroder L, Escrieut C, Pradayrol L, Fourmy D, Silvente-Poirot S (May 2003). "Identification of tyrosine 189 and asparagine 358 of the cholecystokinin 2 receptor in direct interaction with the crucial C-terminal amide of cholecystokinin by molecular modeling, site-directed mutagenesis, and structure/affinity studies". Molecular Pharmacology. 63 (5): 973–82. doi:10.1124/mol.63.5.973. PMID 12695525. S2CID 38395309.

[entrez-10] "Entrez Gene: CCKBR cholecystokinin B receptor".

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