Cholesteryl ester transfer protein

CETP
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 4F2A, 2OBD, 4EWS
Identifiers
Aliases	CETP, BPIFF, HDLCQ10, cholesteryl ester transfer protein
External IDs	OMIM: 118470; HomoloGene: 47904; GeneCards: CETP; OMA:CETP - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q13 Start 56,961,923 bp[1] End 56,983,845 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lymph node spleen liver testicle right lobe of liver monocyte gallbladder left lobe of thyroid gland appendix right lobe of thyroid gland n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function triglyceride binding phosphatidylcholine binding lipid transporter activity phospholipid transporter activity cholesterol binding cholesterol transfer activity lipid binding Cellular component vesicle extracellular region high-density lipoprotein particle extracellular exosome extracellular space Biological process steroid metabolic process phospholipid homeostasis lipid transport lipid metabolism phospholipid transport cholesterol transport cholesterol metabolic process regulation of cholesterol efflux lipid homeostasis very-low-density lipoprotein particle remodeling triglyceride transport cholesterol homeostasis phosphatidylcholine metabolic process triglyceride metabolic process negative regulation of macrophage derived foam cell differentiation triglyceride homeostasis reverse cholesterol transport low-density lipoprotein particle remodeling high-density lipoprotein particle remodeling transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1071 n/a Ensembl ENSG00000087237 n/a UniProt P11597 n/a RefSeq (mRNA) NM_000078 NM_001286085 n/a RefSeq (protein) NP_000069 NP_001273014 n/a Location (UCSC) Chr 16: 56.96 – 56.98 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Cholesteryl ester transfer protein (CETP), also called plasma lipid transfer protein, is a plasma protein that facilitates the transport of cholesteryl esters and triglycerides between the lipoproteins. It collects triglycerides from very-low-density (VLDL) or Chylomicrons and exchanges them for cholesteryl esters from high-density lipoproteins (HDL), and vice versa. Most of the time, however, CETP does a heteroexchange, trading a triglyceride for a cholesteryl ester or a cholesteryl ester for a triglyceride.