Christine Guthrie

Christine Guthrie
Born(1945-04-27)April 27, 1945
Brooklyn, New York
DiedJuly 1, 2022(2022-07-01) (aged 77)
EducationUniversity of Michigan
Alma materUniversity of Wisconsin
Known forGenetics of yeast
SpouseJohn Abelson
AwardsGenetics Society of America Medal
Scientific career
FieldsGenetics
InstitutionsUniversity of California, San Francisco
Doctoral advisorMasayasu Nomura

Christine Guthrie (1945-2022) was an American yeast geneticist and American Cancer Society Research Professor of Genetics at University of California San Francisco.[1] She showed that yeast have small nuclear RNAs (snRNAs) involved in splicing pre-messenger RNA into messenger RNA in eukaryotic cells.[1] Guthrie cloned and sequenced the genes for yeast snRNA and established the role of base pairing between the snRNAs and their target sequences at each step in the removal of an intron.[1] She also identified proteins that formed part of the spliceosome complex with the snRNAs.[1] Elected to the National Academy of Sciences in 1993,[2] Guthrie edited Guide to Yeast Genetics and Molecular Biology, an influential methods series for many years.[3]

  1. ^ a b c d Ares, Manuel. "Genetics Society Award: Christine Guthrie" (PDF). Genetics Society of America. Retrieved October 12, 2018.
  2. ^ "NAS Member Directory:Christine Guthrie". National Academy of Sciences. Retrieved October 12, 2018.
  3. ^ Christine Guthrie, editor (2002) Guide to Yeast Genetics and Molecular and Cell Biology, Part B, Methods in EnzymologyVolume 350 Academic Press.