Chromogranin-A

CHGA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1LV4
Identifiers
Aliases	CHGA, CGA, chromogranin A, Chromogranin A, PHES, PHE5
External IDs	OMIM: 118910; MGI: 88394; HomoloGene: 976; GeneCards: CHGA; OMA:CHGA - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	92,935,285 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	102,531,287 bp
RNA expression pattern
	Top expressed in
	islet of Langerhans; ; primary visual cortex; ; duodenum; ; superior frontal gyrus; ; pituitary gland; ; dorsolateral prefrontal cortex; ; prefrontal cortex; ; Brodmann area 9; ; rectum; ; anterior pituitary;
	Top expressed in
	islet of Langerhans; ; adrenal gland; ; pituitary gland; ; median eminence; ; motor neuron; ; olfactory epithelium; ; neural layer of retina; ; superior frontal gyrus; ; superior cervical ganglion; ; epithelium of stomach;
	More reference expression data
	More reference expression data
Orthologs
	1113
	12652
	ENSG00000276781; ENSG00000100604
	ENSMUSG00000021194
	P10645
	P26339
	NM_001275; NM_001301690
	NM_007693
	NP_001266; NP_001288619; NP_001288619.1
	NP_031719
	Wikidata
View/Edit Human	View/Edit Mouse

Chromogranin-A (CgA) or parathyroid secretory protein 1 is encoded in the human by the gene CHGA. Cga is a member of the granin family of neuroendocrine secretory proteins. As such, it is located in secretory vesicles of neurons and endocrine cells such as islet beta cell secretory granules in the pancreas.^[5]

^ ^a ^b ^c ENSG00000100604 GRCh38: Ensembl release 89: ENSG00000276781, ENSG00000100604 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021194 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Helman LJ, Ahn TG, Levine MA, Allison A, Cohen PS, Cooper MJ, et al. (August 1988). "Molecular cloning and primary structure of human chromogranin A (secretory protein I) cDNA". The Journal of Biological Chemistry. 263 (23): 11559–63. doi:10.1016/S0021-9258(18)37995-X. PMID 3403545.

[refGRCh38Ensembl-1] ENSG00000100604 GRCh38: Ensembl release 89: ENSG00000276781, ENSG00000100604 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021194 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid3403545-5] Helman LJ, Ahn TG, Levine MA, Allison A, Cohen PS, Cooper MJ, et al. (August 1988). "Molecular cloning and primary structure of human chromogranin A (secretory protein I) cDNA". The Journal of Biological Chemistry. 263 (23): 11559–63. doi:10.1016/S0021-9258(18)37995-X. PMID 3403545.

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