Chromosome 8

Chromosome 8
Human chromosome 8 pair after G-banding.
One is from mother, one is from father.
Chromosome 8 pair
in human male karyogram.
Features
Length (bp)146,259,331
(CHM13)[1]
No. of genes646 (CCDS)[2]
TypeAutosome
Centromere positionSubmetacentric[3]
(45.2 Mbp[4])
Complete gene lists
CCDSGene list
HGNCGene list
UniProtGene list
NCBIGene list
External map viewers
EnsemblChromosome 8
EntrezChromosome 8
NCBIChromosome 8
UCSCChromosome 8
Full DNA sequences
RefSeqNC_000008 (FASTA)
GenBankCM000670 (FASTA)

Chromosome 8 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 8 spans about 146 million base pairs (the building material of DNA) and represents between 4.5 and 5.0% of the total DNA in cells.[5]

About 8% of its genes are involved in brain development and function, and about 16% are involved in cancer. A unique feature of 8p is a region of about 15 megabases that appears to have a high mutation rate. This region shows a significant divergence between human and chimpanzee, suggesting that its high mutation rates have contributed to the evolution of the human brain.[5]

  1. ^ "Homo sapiens isolate CHM13 chromosome 8". National Library of Medicine /accessdate=2023-01-13. 4 April 2022.
  2. ^ Cite error: The named reference CCDS was invoked but never defined (see the help page).
  3. ^ Tom Strachan; Andrew Read (2 April 2010). Human Molecular Genetics. Garland Science. p. 45. ISBN 978-1-136-84407-2.
  4. ^ Genome Decoration Page, NCBI. Ideogram data for Homo sapience (850 bphs, Assembly GRCh38.p3). Last update 2014-06-03. Retrieved 2017-04-26.
  5. ^ a b Tabarés-Seisdedos R, Rubenstein JL; Rubenstein (2009). "Chromosome 8p as a potential hub for developmental neuropsychiatric disorders: implications for schizophrenia, autism and cancer". Mol Psychiatry. 14 (6): 563–89. doi:10.1038/mp.2009.2. PMID 19204725. S2CID 11118479.