Clarissa may refer to:
- Clarissa (given name), a female given name
- Clarissa (novel), a novel by Samuel Richardson
- Clarissa (film), a 1941 German film
- Clarissa (TV series), a British television drama series based on the novel
- Clarissa, Minnesota, a small city in the United States
- 302 Clarissa, an asteroid
- Clarissa, an opera based on the Richardson novel by Robin Holloway
- Clarissa, an unfinished novel by Stefan Zweig
- Clarissa, a genus of sawflies in the family Pergidae