Claudin

For the Arthurian character, see Prince Claudin. For the French composer, see Claudin de Sermisy.

Claudins are a family of proteins which, along with occludin, are the most important components of the tight junctions (zonulae occludentes).[1][2] Tight junctions establish the paracellular barrier that controls the flow of molecules in the intercellular space between the cells of an epithelium.[1][3][4] They have four transmembrane domains, with the N-terminus and the C-terminus in the cytoplasm.

  1. ^ a b Hou J, Konrad M (2010-01-01). "Chapter 7 - Claudins and Renal Magnesium Handling". In Yu AS (ed.). Current Topics in Membranes. Vol. 65. Academic Press. pp. 151–176. doi:10.1016/s1063-5823(10)65007-7. ISBN 9780123810397.
  2. ^ Furuse M (2010-01-01). "Chapter 1 - Introduction: Claudins, Tight Junctions, and the Paracellular Barrier". In Yu AS (ed.). Current Topics in Membranes. Vol. 65. Academic Press. pp. 1–19. doi:10.1016/s1063-5823(10)65001-6. ISBN 9780123810397.
  3. ^ Szaszi K, Amoozadeh Y (2014-01-01). "Chapter Six - New Insights into Functions, Regulation, and Pathological Roles of Tight Junctions in Kidney Tubular Epithelium". In Jeon KW (ed.). International Review of Cell and Molecular Biology. Vol. 308. Academic Press. pp. 205–271. doi:10.1016/b978-0-12-800097-7.00006-3. ISBN 9780128000977. PMID 24411173.
  4. ^ Otani T, Nguyen TP, Tokuda S, Sugihara K, Sugawara T, Furuse K, et al. (October 2019). "Claudins and JAM-A coordinately regulate tight junction formation and epithelial polarity". The Journal of Cell Biology. 218 (10): 3372–3396. doi:10.1083/jcb.201812157. PMC 6781433. PMID 31467165.