Clear-cell carcinoma

Clear-cell carcinoma, also known as clear-cell adenocarcinoma and mesonephroma,[1] is an epithelial-cell-derived carcinoma characterized by the presence of clear cells observed during histological, diagnostic assessment. This form of cancer is classified as a rare cancer with an incidence of 4.8% in white patients, 3.1% in black patients, and 11.1% in Asian patients.[2][3]

Clear-cell carcinoma may arise in multiple tissue types including the kidney (clear-cell renal-cell carcinoma), ovary (ovarian clear-cell carcinoma),[4] uterus (uterine clear-cell carcinoma) or gastrointestinal tract (colorectal clear-cell carcinoma).[5]

Treatment options for clear cell carcinoma vary by the tissue type affected. It may include a combination of chemotherapy (paclitaxel and carboplatin or irinotecan plus cisplatin) and surgical resection in ovarian clear-cell carcinoma;[4] debulking or resection paired with chemotherapy (cisplatin) in ovarian clear-cell carcinoma;[2] cytokine therapy (IL-2, interferon), kinase inhibitors (temsirolimus, sunitinib, sorafenib, pazopanib) and anti-angiogenic therapies (bevacizumab).[3]

  1. ^ "Clear cell carcinoma". NCI Dictionary of Cancer Terms. U.S. Department of Health and Human Services, National Institutes of Health, National Cancer Institute (NCI). 2011-02-02.
  2. ^ a b Fujiwara K, Shintani D, Nishikawa T (April 2016). "Clear-cell carcinoma of the ovary". Annals of Oncology. 27 Suppl 1 (suppl_1): i50–i52. doi:10.1093/annonc/mdw086. PMID 27141072.
  3. ^ a b "Clear cell renal cell carcinoma". Genetic and Rare Diseases Information Center (GARD) – an NCATS Program. Genetic and Rare Diseases Information Center (GARD), National Center for Advancing Translational Sciences (NCATS). Retrieved 2019-10-15.
  4. ^ a b Takano M, Tsuda H, Sugiyama T (June 2012). "Clear cell carcinoma of the ovary: is there a role of histology-specific treatment?". Journal of Experimental & Clinical Cancer Research. 31 (1): 53. doi:10.1186/1756-9966-31-53. PMC 3405444. PMID 22655678.
  5. ^ Remo A, Grillo F, Mastracci L, Fassan M, Sina S, Zanella C, et al. (May 2017). "Clear cell colorectal carcinoma: Time to clarify diagnosis". Pathology, Research and Practice. 213 (5): 447–452. doi:10.1016/j.prp.2017.02.013. PMID 28285963.