Clioquinol

Clioquinol
Clinical data
Trade names	Cortin
AHFS/Drugs.com	Micromedex Detailed Consumer Information
MedlinePlus	a682367
Routes of; administration	topical only
ATC code	D08AH30 (WHO) ; D09AA10 (WHO) (dressing) G01AC02 (WHO) P01AA02 (WHO) S02AA05 (WHO);
Legal status
Legal status	UK: POM (Prescription only); US: ℞-only;
Identifiers
	IUPAC name 5-Chloro-7-iodo-quinolin-8-ol;
CAS Number	130-26-7 ;
PubChem CID	2788;
DrugBank	DB04815 ;
ChemSpider	2686 ;
UNII	7BHQ856EJ5;
KEGG	D03538 ;
ChEBI	CHEBI:74460 ;
ChEMBL	ChEMBL497 ;
CompTox Dashboard (EPA)	DTXSID7022837 ;
ECHA InfoCard	100.004.533
Chemical and physical data
Formula	C9H5ClINO
Molar mass	305.50 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Ic1c(O)c2ncccc2c(Cl)c1;
	InChI InChI=1S/C9H5ClINO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4,13H ; Key:QCDFBFJGMNKBDO-UHFFFAOYSA-N ;
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Clioquinol (iodochlorhydroxyquin) tradename Entero-Vioform is an antifungal drug and antiprotozoal drug. It is neurotoxic in large doses. It is a member of a family of drugs called hydroxyquinolines which inhibit certain enzymes related to DNA replication. The drugs have been found to have activity against both viral and protozoal infections.^[2]

^ "Clioquinol topical medical facts from Drugs.com". drugs.com. Retrieved 15 May 2015.
^ Rohde W, Mikelens P, Jackson J, Blackman J, Whitcher J, Levinson W (August 1976). "Hydroxyquinolines inhibit ribonucleic acid-dependent deoxyribonucleic acid polymerase and inactivate Rous sarcoma virus and herpes simplex virus". Antimicrobial Agents and Chemotherapy. 10 (2): 234–240. doi:10.1128/aac.10.2.234. PMC 429727. PMID 185949.

[1] "Clioquinol topical medical facts from Drugs.com". drugs.com. Retrieved 15 May 2015.

[pmid185949-2] Rohde W, Mikelens P, Jackson J, Blackman J, Whitcher J, Levinson W (August 1976). "Hydroxyquinolines inhibit ribonucleic acid-dependent deoxyribonucleic acid polymerase and inactivate Rous sarcoma virus and herpes simplex virus". Antimicrobial Agents and Chemotherapy. 10 (2): 234–240. doi:10.1128/aac.10.2.234. PMC 429727. PMID 185949.

[2]