Cloforex

Cloforex
Skeletal formula
Space-filling model of cloforex
Clinical data
Trade namesFrenapyl, Lipociden, Oberex, Vidipon, Zeisin
Other namesCarbamic acid, N-[2-(4-chlorophenyl)-1,1-dimethylethyl]-, ethyl ester
Routes of
administration		Oral
ATC code
  • none
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
  • ethyl N-[1-(4-chlorophenyl)-2-methylpropan-2-yl]carbamate
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.034.659 Edit this at Wikidata
Chemical and physical data
FormulaC13H18ClNO2
Molar mass255.74 g·mol−1
3D model (JSmol)
Melting point89 °C (192 °F)
Boiling point52.75 °C (126.95 °F)
  • CCOC(=O)NC(C)(C)CC1=CC=C(C=C1)Cl

Cloforex (Oberex) is an anorectic of the amphetamine class.[1] It is a prodrug to chlorphentermine.[2] It never became a mass produced drug in part due to the side effects found in mice. Mice who consumed 75 mg of cloforex a day experienced weight loss along with pulmonary hypertension and hair loss.[3]

  1. ^ Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. ISBN 3-88763-075-0.
  2. ^ Dreyfuss J, Zimmerberg HY, Schreiber EC (1971). "Drug Metabolism.". In Cain CK (ed.). Annual Reports in Medicinal Chemistry. Vol. 6. Boston: Academic Press. pp. 205–214. doi:10.1016/S0065-7743(08)60975-6. ISBN 0-12-040506-7.
  3. ^ Woodward SC (1981). "Induction and reversal of pulmonary lipid histiocytosis in rats following oral administration of anorectics cloforex and chlorphentermine". Journal of Toxicology and Environmental Health. 7 (3–4): 569–583. Bibcode:1981JTEH....7..569W. doi:10.1080/15287398109530002. ISSN 0098-4108. PMID 7197305.