Clorazepate

Clorazepate
Clinical data
Trade namesTranxene, Tranxilium, Novo-Clopate
Other namesClorazepate dipotassium
AHFS/Drugs.comMonograph
MedlinePlusa682052
Routes of
administration
Oral
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability91%
MetabolismHepatic
Elimination half-life48 hours
ExcretionRenal
Identifiers
  • (RS)-7-Chloro-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepine-3-carboxylic acid
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.041.737 Edit this at Wikidata
Chemical and physical data
FormulaC16H11ClN2O3
Molar mass314.73 g·mol−1
3D model (JSmol)
  • O=C(O)C1N=C(c2ccccc2)c2cc(Cl)ccc2NC1=O
  • InChI=1S/C16H11ClN2O3/c17-10-6-7-12-11(8-10)13(9-4-2-1-3-5-9)19-14(16(21)22)15(20)18-12/h1-8,14H,(H,18,20)(H,21,22) checkY
  • Key:XDDJGVMJFWAHJX-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Clorazepate, sold under the brand name Tranxene among others, is a benzodiazepine medication. It possesses anxiolytic, anticonvulsant, sedative, hypnotic, and skeletal muscle relaxant properties. Clorazepate is an unusually long-lasting benzodiazepine and serves as a prodrug for the equally long-lasting desmethyldiazepam, which is rapidly produced as an active metabolite. Desmethyldiazepam is responsible for most of the therapeutic effects of clorazepate.[2]

It was patented in 1965 and approved for medical use in 1967.[3]

  1. ^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
  2. ^ Ochs HR, Greenblatt DJ, Verburg-Ochs B, Locniskar A (October 1984). "Comparative single-dose kinetics of oxazolam, prazepam, and clorazepate: three precursors of desmethyldiazepam". Journal of Clinical Pharmacology. 24 (10): 446–451. doi:10.1002/j.1552-4604.1984.tb01817.x. PMID 6150943. S2CID 24414335. Archived from the original on 2009-07-20. Retrieved 2009-05-31.
  3. ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 536. ISBN 9783527607495.