| Clostridioides difficile toxin B | |||||||
|---|---|---|---|---|---|---|---|
 Structure of C. difficile glucosyl transferase Toxin B showing UDP and glusose from PDB entry 2BVM.[1] | |||||||
| Identifiers | |||||||
| Organism | |||||||
| Symbol | toxB | ||||||
| Alt. symbols | tcdB | ||||||
| Entrez | 4914074 | ||||||
| PDB | 2BVM | ||||||
| RefSeq (Prot) | YP_001087135.1 | ||||||
| UniProt | P18177 | ||||||
| Other data | |||||||
| EC number | 2.4.1.- | ||||||
| Chromosome | genome: 0.79 - 0.8 Mb | ||||||
| |||||||
| TcdB toxin N-terminal helical domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | TcdB_N | ||||||||
| Pfam | PF12918 | ||||||||
| |||||||||
| TcdA/TcdB catalytic glycosyltransferase domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | TcdA_TcdB | ||||||||
| Pfam | PF12919 | ||||||||
| |||||||||
| Peptidase C80 family | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | Peptidase_C80 | ||||||||
| Pfam | PF11713 | ||||||||
| InterPro | IPR020974 | ||||||||
| |||||||||
| TcdA/TcdB pore forming domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | TcdA_TcdB_pore | ||||||||
| Pfam | PF12920 | ||||||||
| TCDB | 1.C.57 | ||||||||
| OPM superfamily | 199 | ||||||||
| OPM protein | 6oq6 | ||||||||
| |||||||||
Clostridioides difficile toxin B (TcdB) is a cytotoxin produced by the bacteria Clostridioides difficile. It is one of two major kinds of toxins produced by C. difficile, the other being a related enterotoxin (Toxin A). Both are very potent and lethal.[2][3]
- ^ Reinert DJ, Jank T, Aktories K, Schulz GE (September 2005). "Structural basis for the function of Clostridium difficile toxin B". Journal of Molecular Biology. 351 (5): 973–81. doi:10.1016/j.jmb.2005.06.071. PMID 16054646.
- ^ Lyerly DM, Krivan HC, Wilkins TD (January 1988). "Clostridium difficile: its disease and toxins". Clinical Microbiology Reviews. 1 (1): 1–18. doi:10.1128/cmr.1.1.1. PMC 358025. PMID 3144429.
- ^ Bartlett JG (1990). "Clostridium difficile: clinical considerations". Reviews of Infectious Diseases. 12 (Suppl 2): S243–51. doi:10.1093/clinids/12.Supplement_2.S243. PMID 2406876.