Cloxazolam

Cloxazolam
Clinical data
Trade names	Akton, Cloxam, Clozal, Elum, Olcadil, and Sepazon
AHFS/Drugs.com	International Drug Names
Routes of; administration	Oral
ATC code	N05BA22 (WHO) ;
Legal status
Legal status	BR: Class B1 (Psychoactive drugs); CA: Schedule IV; DE: Anlage III (Special prescription form required); UK: Class C; US: Schedule IV;
Pharmacokinetic data
Metabolism	Hepatic
Elimination half-life	65 hours
Excretion	Renal
Identifiers
	IUPAC name 10-chloro-11b-(2-chlorophenyl)-2,3,5,7-tetrahydro-[1,3]oxazolo[3,2-d][1,4]benzodiazepin-6-one;
CAS Number	24166-13-0 ;
PubChem CID	2816;
DrugBank	DB01553 ;
ChemSpider	2714 ;
UNII	GYL649Z0HY;
KEGG	D01268 ;
ChEMBL	ChEMBL2107254 ;
CompTox Dashboard (EPA)	DTXSID0022854 ;
Chemical and physical data
Formula	C17H14Cl2N2O2
Molar mass	349.21 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Clc1ccccc1C42OCCN2CC(=O)Nc3c4cc(Cl)cc3;
	InChI InChI=1S/C17H14Cl2N2O2/c18-11-5-6-15-13(9-11)17(12-3-1-2-4-14(12)19)21(7-8-23-17)10-16(22)20-15/h1-6,9H,7-8,10H2,(H,20,22) ; Key:ZIXNZOBDFKSQTC-UHFFFAOYSA-N ;
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Cloxazolam is a benzodiazepine derivative that has anxiolytic, sedative, and anticonvulsant properties.^[3]^[4] It is not widely used; ^[3] as of August 2018 it was marketed in Belgium, Luxembourg, Portugal, Brazil, and Japan.^[1] In 2019, it has been retired from the Belgian market. ^[5]

^ ^a ^b "Cloxazolam International Brands". Drugs.com. Retrieved 13 August 2018.
^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
^ ^a ^b Stolerman IP, ed. (2010). "C: Cloxazolam". Encyclopedia of Psychopharmacology. Berlin: Springer-Verlag. ISBN 978-3-540-68706-1.
^ Richards BL, Whittle SL, Buchbinder R (January 2012). "Muscle relaxants for pain management in rheumatoid arthritis". The Cochrane Database of Systematic Reviews. 1: CD008922. doi:10.1002/14651858.CD008922.pub2. PMID 22258993. S2CID 73769165.
^ "Bon à savoir". cbip.be. Retrieved 13 August 2018.

[brands-1] "Cloxazolam International Brands". Drugs.com. Retrieved 13 August 2018.

[2] Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.

[Stolerman-3] Stolerman IP, ed. (2010). "C: Cloxazolam". Encyclopedia of Psychopharmacology. Berlin: Springer-Verlag. ISBN 978-3-540-68706-1.

[Richards_2012-4] Richards BL, Whittle SL, Buchbinder R (January 2012). "Muscle relaxants for pain management in rheumatoid arthritis". The Cochrane Database of Systematic Reviews. 1: CD008922. doi:10.1002/14651858.CD008922.pub2. PMID 22258993. S2CID 73769165.

[retrait-5] "Bon à savoir". cbip.be. Retrieved 13 August 2018.

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