ClpX

CLPX
Identifiers
Aliases	CLPX, ClpX, caseinolytic mitochondrial matrix peptidase chaperone subunit, EPP2, caseinolytic mitochondrial matrix peptidase chaperone subunit X
External IDs	OMIM: 615611; MGI: 1346017; HomoloGene: 4851; GeneCards: CLPX; OMA:CLPX - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q22.31 Start 65,148,219 bp[1] End 65,185,342 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 C|9 35.22 cM Start 65,201,542 bp[2] End 65,237,940 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm Achilles tendon secondary oocyte amniotic fluid epithelium of colon gastrocnemius muscle gonad ventricular zone right lobe of liver muscle of thigh Top expressed in spermatid spermatocyte left lobe of liver soleus muscle right kidney morula interventricular septum seminiferous tubule muscle of thigh myocardium of ventricle More reference expression data BioGPS n/a
Gene ontology Molecular function unfolded protein binding nucleotide binding protein binding peptidase activator activity metal ion binding ATP-dependent peptidase activity ATPase activity ATP binding Cellular component mitochondrial endopeptidase Clp complex mitochondrial matrix nucleoplasm endopeptidase Clp complex mitochondrial nucleoid mitochondrion cytosol mitochondrial inner membrane Biological process proteolysis involved in cellular protein catabolic process protein folding positive regulation of peptidase activity ATP metabolic process protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10845 270166 Ensembl ENSG00000166855 ENSMUSG00000015357 UniProt O76031 Q9JHS4 RefSeq (mRNA) NM_006660 NM_001044389 NM_011802 RefSeq (protein) NP_006651 NP_006651.2 NP_001037854 NP_035932 Location (UCSC) Chr 15: 65.15 – 65.19 Mb Chr 9: 65.2 – 65.24 Mb PubMed search [3] [4]
Wikidata
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ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial is an enzyme that in humans is encoded by the CLPX gene. This protein is a member of the family of AAA Proteins (AAA+ ATPase) and is to form the protein complex of Clp protease (Endopeptidase Clp).