Coagulative necrosis

Coagulative necrosis is a type of accidental cell death typically caused by ischemia or infarction. In coagulative necrosis, the architectures of dead tissue are preserved for at least a couple of days.[1] It is believed that the injury denatures structural proteins as well as lysosomal enzymes, thus blocking the proteolysis of the damaged cells. The lack of lysosomal enzymes allows it to maintain a "coagulated" morphology for some time. Like most types of necrosis, if enough viable cells are present around the affected area, regeneration will usually occur. Coagulative necrosis occurs in most bodily organs, excluding the brain.[2] Different diseases are associated with coagulative necrosis, including acute tubular necrosis and acute myocardial infarction.[2]

Coagulative necrosis can also be induced by high local temperature; it is a desired effect of treatments such as high intensity focused ultrasound applied to cancerous cells.[3]

  1. ^ V, Abbas AK, Fausto B, Aster JC (2010). Robbins and Cotran: Pathologic Basis of Disease (8th ed.). Elsevier Health Sciences. p. 15. ISBN 978-1-4377-2015-0.
  2. ^ a b Adigun R, Basit H, Murray J (2020). Cell Liquefactive Necrosis. Treasure Island (FL): StatPearls Publishing. PMID 28613685. Retrieved 2020-11-09. {{cite book}}: |work= ignored (help)
  3. ^ Wu F, Wang ZB, Cao YD, Chen WZ, Bai J, Zou JZ, Zhu H (December 2003). "A randomised clinical trial of high-intensity focused ultrasound ablation for the treatment of patients with localised breast cancer". British Journal of Cancer. 89 (12): 2227–33. doi:10.1038/sj.bjc.6601411. PMC 2395272. PMID 14676799.