Cocrystal

In materials science (specifically crystallography), cocrystals are "solids that are crystalline, single-phase materials composed of two or more different molecular or ionic compounds generally in a stoichiometric ratio which are neither solvates nor simple salts."[1] A broader definition is that cocrystals "consist of two or more components that form a unique crystalline structure having unique properties." Several subclassifications of cocrystals exist.[2][3]

Cocrystals can encompass many types of compounds, including hydrates, solvates and clathrates, which represent the basic principle of host–guest chemistry. Hundreds of examples of cocrystallization are reported annually.

  1. ^ Aitipamula, Srinivasulu (2012). "Polymorphs, Salts, and Cocrystals: What's in a Name?". Crystal Growth & Design. 12 (5): 2147–2152. doi:10.1021/cg3002948.
  2. ^ Tilborg, Anaëlle (2014). "How Cocrystallization Affects Solid-State Tautomerism: Stanozolol Case Study". Crystal Growth & Design. 14 (7): 3408–3422. doi:10.1021/cg500358h.
  3. ^ Tilborg, Anaëlle (2014). "Pharmaceutical salts and cocrystals involving amino acids: A brief structural overview of the state-of-art". European Journal of Medicinal Chemistry. 74: 411–426. doi:10.1016/j.ejmech.2013.11.045. PMID 24487190.