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The Cohoquinoque Creek was formerly a stream running west to east through the Callowhill neighborhood in Philadelphia, along the southern part of Northern Liberties and immediately north of original northern boundary of Philadelphia. This small tributary of the Delaware River remains today, as a sewer, under Willow Street, which winds its way through what is sometimes called the East Callowhill Industrial District. Its name, spelled various ways (Cohoquenoque, Cohoquonoque, Cohoquinoke), is said to be derived from a Lenni-Lenape word for "the grove of long pine trees." This was also the name of a nearby Lenape village.
Accounts vary, but Cohoquinoque Creek arose around the present-day intersection of Fifteenth and Spring Garden Streets (and perhaps as far north as Fairmount Avenue) and was also fed by a well-known spring in the Spring Garden district near present-day Ninth Street. The creek was later primarily known as Pegg's Run. Willow Street, a rare curvilinear street in the older part of Philadelphia, is wavy because it follows the course of the old stream. For centuries, Cohoquinoque Creek has often been confused with Cohocksink Creek, which is about a mile to the north.