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| Clinical data | |
|---|---|
| Trade names | Colestid, Cholestabyl |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a682157 |
| Routes of administration | Oral (suspension or tablets) |
| ATC code | |
| Legal status | |
| Legal status |
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| Pharmacokinetic data | |
| Bioavailability | None |
| Excretion | Faeces, in complex with bile acids |
| Identifiers | |
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| CAS Number | |
| PubChem CID | |
| DrugBank | |
| ChemSpider |
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| UNII | |
| KEGG | |
| ChEMBL | |
| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.123.044 |
| Chemical and physical data | |
| Formula | (C4H10N3)m(C3H6O)n |
  (what is this?) (verify) | |
Colestipol (trade names Colestid, Cholestabyl) is a bile acid sequestrant used to lower blood cholesterol, specifically low-density lipoprotein (LDL).[1][2] It is also used to reduce stool volume and frequency, and in the treatment of chronic diarrhea.[3]
Like cholestyramine, colestipol works in the gut by trapping bile acids and preventing them from being reabsorbed. This leads to decreased enterohepatic recirculation of bile acids, increased synthesis of new bile acids by the liver from cholesterol, decreased liver cholesterol, increased LDL receptor expression, and decreasing LDL in blood.[4]
- ^ Handelsman Y (May 2011). "Role of bile acid sequestrants in the treatment of type 2 diabetes". Diabetes Care. 34 (Suppl 2): S244-50. doi:10.2337/dc11-s237. PMC 3632187. PMID 21525463.
- ^ "Colestipol Hydrochloride". Drugs.com.
- ^ "colestipol (Colestid)". MedicineNet.
- ^ Mutschler E, Schäfer-Korting M (2001). Arzneimittelwirkungen (in German) (8th ed.). Stuttgart: Wissenschaftliche Verlagsgesellschaft. p. 523. ISBN 3-8047-1763-2.