| Colicin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Structure of TolB in complex with a peptide of the colicin e9 t-domain | |||||||||
| Identifiers | |||||||||
| Symbol | Colicin | ||||||||
| Pfam | PF03515 | ||||||||
| Pfam clan | CL0446 | ||||||||
| InterPro | IPR003058 | ||||||||
| SCOP2 | 1jch / SCOPe / SUPFAM | ||||||||
| |||||||||
A colicin is a type of bacteriocin produced by and toxic to some strains of Escherichia coli.[1] Colicins are released into the environment to reduce competition from other bacterial strains. Colicins bind to outer membrane receptors, using them to translocate to the cytoplasm or cytoplasmic membrane, where they exert their cytotoxic effect, including depolarisation of the cytoplasmic membrane, DNase activity, RNase activity, or inhibition of murein synthesis.