Colipase

CLPS
Identifiers
AliasesCLPS, entrez:1208, colipase
External IDsOMIM: 120105; MGI: 88421; HomoloGene: 1383; GeneCards: CLPS; OMA:CLPS - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001832
NM_001252597
NM_001252598

NM_025469
NM_001317065

RefSeq (protein)

NP_001239526
NP_001239527
NP_001823

NP_001303994
NP_079745

Location (UCSC)Chr 6: 35.79 – 35.8 MbChr 17: 28.78 – 28.78 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Colipase, abbreviated CLPS, is a protein co-enzyme that counteracts the inhibitory effect of intestinal bile acid on the enzymatic activity of pancreatic lipase. It is secreted by the pancreas in an inactive form, procolipase, which is activated in the intestinal lumen by trypsin.

Intestinal bile acids (which aid lipid digestion by facilitating micelle formation) adhere to the surface of emulsified fat droplets, displacing lipase (which is only active at the water-fat interface) from the droplet surface. Colipase acts as a bridging molecule, binding to both lipase and bile acids, thus anchoring lipase onto the droplet surface, preventing its displacement.[5]

In humans, the colipase protein is encoded by the CLPS gene.[6]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000137392Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024225Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Koeppen, Bruce M.; Stanton, Bruce A.; Swiatecka-Urban, Agnieszka, eds. (2024). Berne & Levy Physiology (8th ed.). Philadelphia, PA: Elsevier. ISBN 978-0-323-84790-2.
  6. ^ Davis RC, Xia YR, Mohandas T, Schotz MC, Lusis AJ (May 1991). "Assignment of the human pancreatic colipase gene to chromosome 6p21.1 to pter". Genomics. 10 (1): 262–5. doi:10.1016/0888-7543(91)90509-D. PMID 2045105.