Colipase

CLPS
Identifiers
Aliases	CLPS, entrez:1208, colipase
External IDs	OMIM: 120105; MGI: 88421; HomoloGene: 1383; GeneCards: CLPS; OMA:CLPS - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	35,797,344 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	28,779,740 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; islet of Langerhans; ; testicle; ; pancreatic epithelial cell; ; beta cell; ; right coronary artery; ; ectocervix; ; right uterine tube; ; Descending thoracic aorta; ; right lobe of liver;
	Top expressed in
	stomach; ; islet of Langerhans; ; jejunum; ; duodenum; ; colon; ; ileum; ; esophagus; ; morula; ; quadriceps femoris muscle; ; yolk sac;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	enzyme activator activity;
Cellular component	extracellular region;
Biological process	lipid catabolic process; digestion; positive regulation of catalytic activity; lipid metabolism; response to food; response to bacterium; retinoid metabolic process; lipid digestion;
	Sources:Amigo / QuickGO
Orthologs
	1208
	109791
	ENSG00000137392
	ENSMUSG00000024225
	P04118
	Q9CQC2
	NM_001832; NM_001252597; NM_001252598
	NM_025469; NM_001317065
	NP_001239526; NP_001239527; NP_001823
	NP_001303994; NP_079745
	Wikidata
View/Edit Human	View/Edit Mouse

Colipase, abbreviated CLPS, is a protein co-enzyme that counteracts the inhibitory effect of intestinal bile acid on the enzymatic activity of pancreatic lipase. It is secreted by the pancreas in an inactive form, procolipase, which is activated in the intestinal lumen by trypsin.

Intestinal bile acids (which aid lipid digestion by facilitating micelle formation) adhere to the surface of emulsified fat droplets, displacing lipase (which is only active at the water-fat interface) from the droplet surface. Colipase acts as a bridging molecule, binding to both lipase and bile acids, thus anchoring lipase onto the droplet surface, preventing its displacement.^[5]

In humans, the colipase protein is encoded by the CLPS gene.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000137392 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024225 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Koeppen, Bruce M.; Stanton, Bruce A.; Swiatecka-Urban, Agnieszka, eds. (2024). Berne & Levy Physiology (8th ed.). Philadelphia, PA: Elsevier. ISBN 978-0-323-84790-2.
^ Davis RC, Xia YR, Mohandas T, Schotz MC, Lusis AJ (May 1991). "Assignment of the human pancreatic colipase gene to chromosome 6p21.1 to pter". Genomics. 10 (1): 262–5. doi:10.1016/0888-7543(91)90509-D. PMID 2045105.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000137392 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024225 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[:22-5] Koeppen, Bruce M.; Stanton, Bruce A.; Swiatecka-Urban, Agnieszka, eds. (2024). Berne & Levy Physiology (8th ed.). Philadelphia, PA: Elsevier. ISBN 978-0-323-84790-2.

[pmid2045105-6] Davis RC, Xia YR, Mohandas T, Schotz MC, Lusis AJ (May 1991). "Assignment of the human pancreatic colipase gene to chromosome 6p21.1 to pter". Genomics. 10 (1): 262–5. doi:10.1016/0888-7543(91)90509-D. PMID 2045105.

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