Collier's sign

Collier's sign
SymptomsThe sclera can be seen above the cornea, and further upgaze increases the distance between the eyelids and irises.
CausesUpper dorsal midbrain supranuclear lesions such as Parinaud's syndrome, 'top of the basilar syndrome', midbrain infarction, neurodegeneration or tumour, multiple sclerosis, encephalitis, and Miller-Fisher syndrome. Damage to the posterior commissure levator inhibitory fibres which originate in the M-group of neurons.
Differential diagnosisMidbrain lesion

Collier's sign (also known as Collier's tucked lid sign[1] or posterior fossa stare[2]) is bilateral or unilateral eyelid retraction.

It is an accepted medical sign of a midbrain lesion, first described in 1927 by J Collier.[3] With the eyes in the primary position, the sclera can be seen above the cornea, and further upgaze increases the distance between the eyelids and irises.[4] Causes include upper dorsal midbrain supranuclear lesions such as Parinaud's syndrome, 'top of the basilar syndrome',[2] midbrain infarction, neurodegeneration or tumour, multiple sclerosis, encephalitis, and Miller-Fisher syndrome.[5] The cause is thought to be damage to the posterior commissure levator inhibitory fibres[2] which originate in the M-group of neurons.[4]

  1. ^ Cite error: The named reference biology-online.org was invoked but never defined (see the help page).
  2. ^ a b c Cite error: The named reference Larner-2010 was invoked but never defined (see the help page).
  3. ^ J. Collier, Nuclear Ophthalmoplegia with special reference to retraction of the lids and ptosis and to lesions of the posterior commissure. Brain (journal) 1927; 50; 488 - 498.
  4. ^ a b Cite error: The named reference Wray was invoked but never defined (see the help page).
  5. ^ Cite error: The named reference Miyashi-2006 was invoked but never defined (see the help page).